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Geographic information systems GIS are being used with increasing frequency in environmental epidemiology studies. Reported applications include locating the study population by geocoding addresses assigning mapping coordinates , using proximity analysis of contaminant source as a surrogate for exposure, and integrating environmental monitoring data into the analysis of the health outcomes. Although most of these studies have been ecologic in design, some have used GIS in estimating environmental levels of a contaminant at the individual level and to design exposure metrics for use in epidemiologic studies. In this article we discuss fundamentals of three scientific disciplines instrumental to using GIS in exposure assessment for epidemiologic studies: We also explore how a GIS can be used to accomplish several steps in the exposure assessment process.